Relationship of PCSK9 and MTRR Variants with Myocardial Infarction in Southern Punjab Population of Pakistan

Authors

  • Saba Zafar Department of Biochemistry and Biotechnology, The Women University, Multan
  • Madiha Fatima Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan
  • Rehan Sadiq Shaikh Center for Applied Molecular Biology, University of the Punjab, Lahore

Keywords:

PCSK9, MTRR, Myocardial Infarction

Abstract

Myocardial infarction (MI) being the most common disease is leading cause of mortality across the world, being a multifactorial disease. it is caused by several environmental and genetic factors.We investigated the association of single nucleotide polymorphism in PCSK9 and MTRR and the effects of different demographic factors like age, gender, education, family history, hypertension, diabetes and smoking habit with Myocardial Infarction in 200 individuals suffering from of MI and 155 healthy individuals. The polymerase chain reaction technique was used with TETRA-ARMS primers to investigate the single nucleotide polymorphism, and genotypes of individuals in the PCSK9 and MTRR genes. There is a significant difference in the genotypic frequency of SNP rs2479409 and rs1801394 in patients and normal individuals (P <0.05). Our results also indicate that both polymorphisms of PCSK9 and MTRR were associated with risk of MI in the population of Southern Punjab, Pakistan

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Published

04-10-2023

How to Cite

Zafar, S., Fatima, M., & Shaikh, R. S. (2023). Relationship of PCSK9 and MTRR Variants with Myocardial Infarction in Southern Punjab Population of Pakistan. III. International Congress of the Turkish Journal of Agriculture - Food Science and Technology, Malatya, Türkiye, 309–309. from https://turjaf.com/index.php/TURSTEP/article/view/179

Congress

III. International Congress of the Turkish Journal of Agriculture - Food Science and Technology, Malatya, Türkiye

Section

Presentations Online