Türkiye'den Consolida orientalis'in İn Vitro Tirozinaz ve Kollajenaz İnhibitör Potansiyeli

Abstract

The cosmetics sector is showing significant growth especially on skin aging. For this reason, it is known that studies on natural products that prevent aging and pigmentation are popular research areas. Antioxidants protect our skin from free radicals and help us prevent signs of aging and skin tone inequalities. High tyrosinase inhibition has a whitening effect on the skin, while collagenase inhibition has an anti-sagging effect on the skin. Antioxidant activity and tyrosinase/collagenase enzyme inhibition capacities support each other. This study aimed to determine the tyrosinase and collagenase enzyme inhibition potentials of ethanol extracts of Consolida orientalis flowers, whose antioxidant activity has been proven in the literature. In the study; kojic acid was used as the standard substance for anti-tyrosinase activity, and quercetin was used as the standard substance for anti-collagenase activity. According to the enzyme inhibitory capacity results measured with both analyses; anti-tyrosinase activity was determined as 13.0% and anti-collagenase activity as 23.2%. These results have shown us that the flowers of C. orientalis have the potential to inhibit tyrosinase and collagenase enzymes, although not at a high level. C. orientalis deserves further study and can be considered as a new candidate for the development of plant-based products for the management of hyperpigmentation and skin aging.

Key Words: Collagenase, Consolida orientalis, Tyrosinase, Natural cosmetics